When we think of the metabolism, almost no one mentions leptin resistance or mitochondrial function, however, these 2 things are basic & vital when it comes to a healthy metabolism. For max mitochondrial function, we also want max melatonin production (this shrinks the space between respiratory proteins in the mitochondria) & eating something that raises your insulin will not only block melatonin production, it will also compete with leptin at the hypothalamus for docking space.